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文献名称

多囊卵巢综合征中的D手性肌醇及其意义:系统性综述 [下载]
 
D-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review
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文献简介

出版社:Gynecological Endocrinology

作者:NICOLAS GALAZIS1 , MYRIA GALAZI 2 , & WILLIAM ATIOMO

编号:10.3109/09513590.2010.538099

关键字:D-chiro-inositol, DCI, PCOS, polycystic, ovary, syndrome, review

年份:2011点击量:1813

文献摘要

Background. 

          The pathogenesis of polycystic ovary syndrome (PCOS) has been linked to the development of insulin resistance and hyperinsulinemia. The objective of this study is to investigate the effects of insulin sensitising agents such as D-chiro-inositol (DCI) on ovulation and insulin resistance in women with PCOS.

背景:

          多囊卵巢综合征(PCOS)的发病机制被证实与胰岛素抵抗和高胰岛素血症的发展有关。本研究旨在探讨胰岛素增敏剂对PCOS女性患者排卵和胰岛素抵抗的影响,如D手性肌醇(DCI)。

 

Methods. 

          This was a systematic review done in an Academic Department of Obstetrics and Gynaecology in the UK of all studies published on PCOS and DCI up till May 2010. Patients were women with PCOS receiving DCI or where the relationship between insulin resistance and DCI had been investigated. Ovulation rates and changes in insulin sensitivity were the main outcome measures.

方法:

          本研究系统性地回顾了截止到2010年5月,英国妇产科学术部所有关于PCOS和DCI的已版研究。研究中,多囊卵巢综合征的女性患者接受了DCI或者对胰岛素抵抗和DCI之间关系进行了调查。排卵率和胰岛素敏感度的变化作为主要结果测定。

 

Results. 

          Less DCI-IPG was released in PCOS women compared to controls and this seems to correlate positively with insulin resistance and hyperinsulinemia evident in these patients. DCI administration had beneficial effects on ovulation, anthropometric and metabolic markers in PCOS women by enhancing insulin. The effects of metformin in improving insulin action in PCOS women was achieved though the release of DCI-IPG mediators.

结果:

          与对照组相比,PCOS女性患者的DCI-IPG流失较少,这似乎与这些患者中胰岛素抵抗和高胰岛素血症有明显正相关性。DCI给药增强胰岛素有利于PCOS女性患者的排卵、人体测量和代谢指标。虽然释放了DCI-IPG介质,但二甲双弧在改善PCOS女性患者胰岛素功能上达到了疗效。

 

Conclusions. 

          Heterogeneity observed in the methodologies of each study, the scarcity of relevant studies and the small sample sizes used prohibit reliable conclusions to be drawn. Therefore, more studies must be conducted in the future to evaluate accurately the effects of DCI in PCOS.

结论:

          在每项研究方法中观察到的异质性,通过相关研究的匮乏以及禁止使用小样本得出了可靠的结论。因此,未来需进一步研究来准确评估DCI对PCOS患者的作用。

 

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