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美国路易斯安那州西北部退伍高血压军人中的类Liddle综合征表型的高患病率 [下载]
 
High Prevalence of Liddle Syndrome Phenotype Among Hypertensive US Veterans in Northwest Louisiana
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文献简介

出版社:THE JOURNAL OF CLINICAL HYPERTENSION

作者:Miha´ ly Tapolyai, MD;As¸ kin Uysal, MD;Neville R. Dossabhoy, MD

编号:10.1111/j.1751-7176.2010.00359.x

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年份:2010点击量:1703

文献摘要

     Liddle syndrome (LS) is an autosomal dominant disorder due to a gain-of-function mutation in the epithelial Na+ channel and is perceived to be a rare condition. A cross-sectional study of 149 hypertensive patients with hypokalemia (<4mmol ⁄ dL) or elevated serum bicarbonate (>25 mmol ⁄ dL) was conducted at a Veterans’Administration Medical Center Hypertension Clinic in Shreveport, LA. Data on demographics, blood pressure, and select blood tests were collected and expressed as percentages for categoric variables and as mean standard deviation (SD) for continuous variables. Patients were diagnosed with likely LS when the plasma renin activity (PRA) was <0.35μU⁄⁄mL⁄ hand the aldosterone was <15 ng ⁄ dL and likely primary hyperaldosteronism (PHA) with PRA<0.35 μU⁄mL⁄ h and aldosterone level >15 ng ⁄ dL. The cohort included predominantly elderly (67.1±13.4 years), male (96%), and Caucasian (57%) patients. The average blood pressure was 143.8 ⁄ 79.8 mm Hg±27.11 ⁄ 15.20 with 3.03±1.63 antihypertensive drugs. Based on the above criteria, 9 patients (6%) satisfied the criteria for likely LS and 10 patients (6.7%) were diagnosed with likely PHA. In this hypothesis-generating study, the authors detected an unusually high prevalence of biochemical abnormalities compatible with likely LS syndrome from Northwestern Louisiana, approaching that of likely PHA.

     Liddle综合征(LS)是一种由上皮钠离子通道获得性功能突变的常染色体显性遗传疾病,,属于罕见疾病。在路易斯安那的什里夫波特的一个退伍军人医学中心高血压诊所内,对149例伴低钾血(<4mmol ⁄ dL)或血清碳酸氢盐(>25 mmol ⁄ dL)的高血压患者进行一项横断面研究。收集人口统计学、血压、选择血液试验的数据,采用分类变量百分比和连续变量的平均标准偏差(SD)来表示。当血浆肾素活性(PRA<0.35μ.⁄ mL ,醛固酮<15ng ⁄ dL时,患者患者被诊断为类Liddle综合征,另外,类原发性醛固酮增多症(PHA)的PRA<0.35μ.⁄mL⁄ h,醛固酮水平>15 ng ⁄ dL。本次研究对象以老年患者为主(67.1对象Lh4岁),男性占96%,白人占57%。在降压药物给药3.03± 1.63的情况下,患者的平均血压为143.8 ⁄ 79.8 mm Hg ±27.11 ⁄ 15.20基于上述标准,9例(6)达到类 Liddle综合征的相应标准,10例(6.7)被诊断为类PHA。在这项假设研究中,研究人员发现在路易斯安那西北部,与类Liddle综合征相似的生化异常具有一个不寻常的高患病率,接近于类PHA

 

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